Knee Comfort & Mobility Study for Active Adults

A 12-week, at-home study comparing NT-II™ marine collagen with glucosamine–chondroitin

Join a fully remote study comparing a marine-derived collagen supplement with glucosamine–chondroitin to see how these supplements may support activity-related knee comfort and mobility in healthy adults.

See If You Qualify
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About This Study

At-Home Study
No clinic visits. Everything is shipped to your door. You’ll complete online check-ins and use easy home testing kits throughout the study.
Required Wearable Device
If you own a compatible device (Fitbit, Garmin, Apple Watch, or Oura ring) you must connect it to provide activity metrics alongside your surveys.
Participant Compensation
Participants who meet adherence requirements will receive a $20 Amazon gift card after completing the 7-day screening study and an additional $120 upon completing the 12-week main study, if eligible.
Data Collected
Daily surveys collected on the Alethios platform.

What's Involved

The study begins with a 1-week screening phase. During this time, participants will connect a compatible wearable device (Apple watch, Fitbit, Garmin, Oura Ring, Whoop or GoogleFit) complete short daily knee-comfort ratings, and track activity for 7 days. Those who complete all screening activities will receive a $20 Amazon gift card. Participants who qualify will then be randomized to NT-II™ 240 mg, NT-II™ 480 mg, or glucosamine–chondroitin, taken once daily with food for 12 weeks. During the main study, you’ll complete weekly knee-comfort surveys, sync wearable data, and use the Curovate app to measure knee range of motion at the beginning and end of the study. Participants who complete all required activities in the main study will receive a $120 Amazon gift card.

Verify Eligibility and Enroll

Complete a short screening questionnaire through our online platform to confirm eligibility for the study. If eligible, you’ll review the study details and sign an electronic consent form through the Alethios platform.

Complete Screening Run-In Period

During this 7-day screening phase, you’ll connect your wearable device and complete a short daily survey. Participants who meet adherence requirements will receive a $20 Amazon gift card, even if not enrolled in the main study.

Enroll in Main Study

After the research team reviews your results from the 7-day run-in period, you may be enrolled in the main study. If selected, you’ll confirm or deny your willingness to participate and complete knee range of motion measurements at baseline, week 6, and week 12, along with daily discomfort assessments.

Study Close and Compensation

After completing all study requirements, adherent participants will receive a $120 Amazon gift card and access to their individual study data.

What's Being Studied?

NT-II™ is a marine-derived undenatured type II collagen. This study is testing whether taking NT-II™ daily can support knee comfort and mobility during activity, compared with glucosamine–chondroitin. Over 12 weeks, researchers will look at weekly knee-comfort ratings, wearable-captured activity metrics and knee range of motion.

Am I eligible?

You may be eligible if you meet the following requirements

See If You Qualify
Adults with reproducible, activity-related knee discomfort
Are not pregnant or breastfeeding
Are willing to take the supplement daily and complete surveys
No fish or shellfish allergy.
Willing and able to wear a smartwatch/compatible device during the study.
Not using joint-related supplements/medications that may interfere
Are 20 to 65 years of age

More about this study

Learn more about this study at the US government's clinical trial registry

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